Adrenergic (Sympathomimetic) Drugs
2006; Elsevier BV; Linguagem: Inglês
10.1016/b978-044452166-8/50011-x
AutoresRuben Vardanyan, Victor J. Hruby,
Tópico(s)Receptor Mechanisms and Signaling
ResumoAdrenergic drugs are natural or synthetic compounds that either partially or completely replicates the effects of norepinephrine, epinephrine, and dopamine. These drugs cause a biological response similar to the activation of the sympathetic nervous system. These are also referred to as sympathomimetic because they mimic the stimulation of the sympathetic nervous system. The sympathetic nervous system plays an important role in the involuntary regulation of cardiac activity, vascular tonicity, functional activity of smooth muscle, and glands by releasing endogenic adrenergic substances, catecholines, from peripheral nerve endings into the synapses of the central nervous system. The correlations between the structure of sympathomimetic and the biological activity exhibited by them are sympathomimetic activity is maximal when there are two carbon atoms between the aromatic ring and the amino group. The chapter discusses the direct acting Agonists such as isotharine, terbutaline, metaproterenol, ritodrine, and Antiedema, along with sympathomimetic such as antiedema agents for the mucous membranes, naphazoline, oxymethazoline, tetrahydrozoline, and xylomethazoline.
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