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Microbial Persistence or Phenotypic Adaptation to Antimicrobial Agents: Cystic Fibrosis as an Illustrative Case

1989; Springer Science+Business Media; Linguagem: Inglês

10.1007/978-3-642-74095-4_17

1865-0325

L E Bryan,

Cystic Fibrosis Research Advances

This chapter considers adaptive changes which allow microorganisms to persist despite apparently effective antimicrobial therapy by in vitro testing. Such changes are normally manifest mainly during the course of therapy but in some instances may be stable beyond its termination. Even in the latter circumstances when bacterial colonization continues, isolates expressing lower susceptibility are often replaced by more susceptible organisms.