Allosteric Interactions of Muscarinic Receptors and Their Regulation by Other Membrane Proteins
1989; Humana Press; Linguagem: Inglês
10.1007/978-1-4612-4498-1_10
AutoresYoav I. Henis, Yoel Kloog, Mordechai Sokolovsky,
Tópico(s)Ion channel regulation and function
ResumoThe complex nature of ligand binding to muscarinic acetylcholine (ACh) receptors in various tissues and the battery of compounds with antimuscarinic activity that affect muscarinic binding sites in a manner that does not fit simple competition (reviewed by Sokolovsky, 1984) suggest the possible existence of cooperative and allosteric interactions in the muscarinic system. In this review, we will discuss the current evidence and the experimental approaches (up to early 1987) employed to investigate such interactions in the muscarinic receptor system.
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