Portal de Periódicos da CAPES

Development of the Embryonic Murine Kidney in Normal and Congenital Polycystic Kidney Disease: Characterization of a Proximal Tubular Degenerative Process as the First Observable Light Microscopic Defect

1984; Lippincott Williams & Wilkins; Volume: 131; Issue: 1 Linguagem: Inglês

10.1016/s0022-5347(17)50250-5

1527-3792

Rael Nidess, William E. Koch, Floyd A. Fried, Eleanor C. McFarland, James Mandell,

Pediatric Urology and Nephrology Studies

No AccessJournal of Urology1 Jan 1984Development of the Embryonic Murine Kidney in Normal and Congenital Polycystic Kidney Disease: Characterization of a Proximal Tubular Degenerative Process as the First Observable Light Microscopic Defect Rael Nidess, William E. Koch, Floyd A. Fried, Eleanor McFarland, and James Mandell Rael NidessRael Nidess More articles by this author , William E. KochWilliam E. Koch More articles by this author , Floyd A. FriedFloyd A. Fried More articles by this author , Eleanor McFarlandEleanor McFarland More articles by this author , and James MandellJames Mandell More articles by this author View All Author Informationhttps://doi.org/10.1016/S0022-5347(17)50250-5AboutPDF ToolsAdd to favoritesDownload CitationsTrack CitationsPermissionsReprints ShareFacebookLinked InTwitterEmail The current report presents findings from a comparative histological and histochemical investigation of murine congenital polycystic kidney disease. The studies revealed that the morphological changes are initiated in the developing proximal tubules of the nephron; differences from control sections first become evident at 16 days’ gestation. As the disease progresses, obvious changes include hyperplasia and dilation of the tubule, cellular vacuolization, and alterations in the apical cell brush border. Included among the latter changes are decreases in enzyme (alkaline phosphatase) staining and decreases in glycoprotein staining (periodic acid Schiff). All such changes continue until the kidney is markedly cystic and apical cell cytochemical staining is absent. Some cellular vacuolization, assumed to be a normal developmental event, is also seen within the same segment of the proximal tubule at 17 days’ gestation through the 1st postnatal day. Dilation of the collecting duct is noted to be a later or secondary change evident after the initial onset of the disease. © 1984 by The American Urological Association Education and Research, Inc.FiguresReferencesRelatedDetailsCited byFry J, Koch W, Jennette J, Mcfarland E, Fried F and Mandell J (2018) A Genetically Determined Murine Model of Infantile Polycystic Kidney DiseaseJournal of Urology, VOL. 134, NO. 4, (828-833), Online publication date: 1-Oct-1985. Volume 131Issue 1January 1984Page: 156-162 Advertisement Copyright & Permissions© 1984 by The American Urological Association Education and Research, Inc.MetricsAuthor Information Rael Nidess More articles by this author William E. Koch More articles by this author Floyd A. Fried More articles by this author Eleanor McFarland More articles by this author James Mandell More articles by this author Expand All Advertisement PDF downloadLoading ...