Portal de Periódicos da CAPES

Chapter 66 Neural transplantation (auto-adrenal, fetal nigral and fetal adrenal) in Parkinson's disease: the Mexican experience

1990; Elsevier BV; Linguagem: Inglês

10.1016/s0079-6123(08)62649-7

1875-7855

Ignacio Madrazo, Rebecca E. Franco-Bourland, Feggy Ostrosky‐Solís, Maricarmen Aguilera, Carlos Cuevas, Fausto Álvarez, Eduardo Magallón, Carlos Zamorano, Alfonso Morelos,

Nerve injury and regeneration

This chapter examines neural transplantation in Parkinson's disease (PD). In the study described in the chapter, 34 male and 8 female PD patients were selected for surgery. They had at least 3 of the 4 major PD symptoms, a Unified Parkinsonism Rating Scale (UPRS) score of less than 120 points in the “off” condition, a 50% response to L-dopa treatment for at least 3 hours, and a respiratory restriction because of rigidity during “off” of less than 40%. Using the same surgical technique in all cases, 39 patients received grafts to the right caudate nucleus (CN) and 3 to the left caudate, because of right sided predominance of the disease. An Ommaya-like reservoir was placed in 15 patients for ventricular fluid sampling. The statistical analyses of the clinical data were done with the Student's paired t test, the Wilcoxon's test for paired samples, and Rankit's normal order statistics. Neuropsychological data were analyzed using the Mann–Whitney U-test. Biochemical data were analyzed using student's t-test, student's paired t-test, and the analysis of variance (ANOVA) test. Biochemical assessments led to the identification of a neurite outgrowth promoting activity (NOPA).