Crystalline and Amorphous Solids
2017; Elsevier BV; Linguagem: Inglês
10.1016/b978-0-12-802447-8.00002-9
Autores Tópico(s)Analytical Chemistry and Chromatography
ResumoOf the several states of matter in which a substance can reside, the solid state is most commonly encountered; therefore, it is the most important and relevant state for pharmaceutical development. Most of the pharmaceutical products on the market or formulations presently being developed are in the solid dosage form. Even when a product is marketed or developed as a solution or a semisolid formulation, a solid is usually selected and manufactured as an active pharmaceutical ingredient for such reasons as the ability to crystallize (and therefore to be purified), ease of handling, and better chemical stability in comparison with liquids. Therefore, an understanding of the various solid forms that may occur, as well as the rational selection of solid forms for development, are critical to the facile development of a particular chemical entity. Many books and special journal issues are devoted to this topic. This chapter, due to space limitations, provides only a brief introduction to the fundamental principles and practical aspects of pharmaceutical solids. Interested readers are encouraged to read the books and reviews cited here.
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