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Response of Cells in Vitro and Tissues in Vivo to Hyperthermia and X-Irradiation

1976; Elsevier BV; Linguagem: Inglês

10.1016/b978-0-12-035406-1.50010-5

0065-3292

Donald Ε. Thrall, Leo E. Gerweck, Edward L. Gillette, William C. Dewey,

Cellular Mechanics and Interactions

It has been reported that heat and radiation together as a modality can be used to treat human cancer. However, a preferred time and dose relationship for combined treatment has not been developed. This has been largely a result of the inability to quantify the lethal effects of heat alone or in combination with radiation. As a result, heat alone or combined with radiation, at its present state of development, is an unacceptable alternative for the treatment of cancer. Therefore, this chapter reviews quantitatively the interaction of heat and radiation on an in vitro and an in vivo system. The objectives are to evaluate the following parameters: (1) the sensitivity of cells to heat killing under oxygenated or hypoxic conditions, (2) the radiation killing of cells before, during, or after heating, (3) the importance of the time interval between the two modalities, (4) the effect of cell progression and division on the repair of heat damage, (5) the effect of heat on both normal tissue and tumor tissue in vivo, and (6) the possibility that heat combined with radiation could improve the radiotherapeutic ratio of tumor damage to skin damage.